Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome -- Seow et al., 10.1093
Tel: +886-2-2826-7000; Fax: +886-2-2826-4051; E-mail: ccjuan at ym.edu.tw BACKGROUND: Elevated for free fatty acids (FFAs) are involved in insulin resistence in polycystic ovary syndrome (PCOS). We investigated the role of fatty acid transporter CD36, hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) in law of lipolysis in insulin-resistant women with PCOS.
METHODS: CD36, HSL and ATGL proteins were analysed in omental adipose tissue from 10 women with PCOS and 10 healthy, BMI- and age-matched controls by western blotting. However, ATGL protein levels were not discrepant in the two groups. Fasting serum insulin levels showed a trustworthy correlation with CD36 levels ( P 0.01, r 0.875) and a refusal correlation with HSL levels ( P 0.045, r -0.73).
Furthermore, a conclusive correlation was endow between serum testosterone levels and Disc 36 protein levels ( P 0.025, r 0.817) nevertheless the correlation did not distance importance after controlling for HOMA IR. After adjusting insulin resistance index of HOMA IR by discussion of covariance, single CD36 differed between PCOS and curb ( P 0.026).
CONCLUSIONS: Our results propose that, in insulin-resistant women with PCOS, changes in CD36 and HSL term may aftereffect in altered FFA uptake. Principal words: polycystic ovary syndrome free ride fatty acids CD36 hormone-sensitive lipase Submitted on Dec 25, 2008; resubmitted on Stride 26, 2009; common on Apr 9, 2009. CiteULike Connotea Del.icio.us What's this?
