Treatment for cervical intraepithelial neoplasia and subsequent IVF deliveries -- Jakobsson et al., 10.1093 humrep den271 -- Human Reproduction
The Author 2008. Published by Oxford University Press on behalf of the European State of Human Reproduction and Embryology. All rights reserved.
For Permissions, please email: journals.permissions oxfordjournals.org Treatment for cervical intraepithelial neoplasia and subsequent IVF deliveries Maija Jakobsson 1, 4, Mika Gissler 2, 3, Aila Tiitinen 1, Jorma Paavonen 1 and Anna-Maija Tapper 1 1 Branch of Obstetrics and Gynaecology, University Hospital, PO Box 140, FIN-00029 Helsinki, Finland 2 STAKES Governmental Proof and Buildup Middle for Welfare and Health, PO Box 220, Helsinki, Finland 3 Nordic Faculty of Accepted Health, Gothenburg, Sweden 4 Dispatch address.
E-mail: maija.jakobsson at fimnet.fi BACKGROUND: The objective was to glance at if the treatment of cervical intraepithelial neoplasia (CIN) is associated with a subsequent cumulation in the employ of IVF to actualize deliveries and whether women with cervical treatment and IVF hog increased rates of preterm delivery. METHODS: This was a register-based retrospective cohort ( n 822 183 deliveries) glance at from Finland whose leading outcome measures were the rates of IVF and preterm deliveries in discrepant CIN treatment groups.
RESULTS: Of all deliveries in Finland, 1.5% (12 240) resulted from IVF treatment. This proportion was 1.6% for women who had undergone any cervical procedure n 150, risk ratio (RR): 1.21, confidence period (CI): 1.04-1.42. The risk for IVF was not increased after cervical conization, whether by loop or laser (1.6%), or ablation (1.8%).
An increased digit of IVF deliveries (2.7%) was observed succeeding other excisional treatments, yet when adjusted for year of delivery (RR: 1.83, CI: 1.16-2.89) or parity (RR: 1.95, CI: 1.25-3.04). Although women who had undergone any cervical procedure and IVF appeared to acquire an increased relative risk for preterm delivery (3.42-fold, CI: 2.18-5.37) when compared with women with neither, this was explained by maternal lifetime and parity.
CONCLUSIONS: The proportion of IVF deliveries was not increased after cervical conization or ablation. This is reassuring for blooming women who undergo such treatments. Explanation words: treatment for CIN conization subfertility IVF preterm delivery Submitted on Dec 12, 2007; resubmitted on May 30, 2008; universal on Jun 9, 2008. CiteULike Connotea Del.icio.us What's this?
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