Real and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis -- Verpoest et al., 10.1093 humrep den105 -- Human
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For Permissions, please email: journals.permissions oxfordjournals.org Essential and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis W. Verpoest 1, 6, M. De Rademaeker 2, K. Sermon 3, M. De Rycke 3, S. Seneca 2, E. Papanikolaou 4, C. Spits 2, L. Automobile Landuyt 1, J. Vehivle der Elst 1, P. Haentjens 5, P. Devroey 1 and I.
Liebaers 2 1 Middle for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, UZ Brussel, 101 Laarbeeklaan, B-1090 Brussel, Belgium 2 Centre for Medical Genetics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium 3 Branch of Embryology and Genetics, Vrije Universiteit Brussel, Belgium 4 Centre for Assisted Reproduction "Biogenesis", Genesis Hospital, Thessaloniki, Greece 5 Centre for Outcomes Trial and Laboratory for Experimental Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium 6 Dispatch address.
METHODS: Prospective cohort study. De facto and expected cumulative delivery rates are descriptive. The reproductive outcome per cycle was compared with that of a charge troop of patients with X-linked recessive disorders.
The comparative argument of ovarian stimulation parameters in the glance at body versus the domination cartel was carried elsewhere using both bivariate (crude) and multivariate (linear regression) analysis. RESULTS: Between 1995 and 2005, 205 cycles of ICSI and PGD were carried away for DM1 in 78 couples. The essential cumulative delivery proportion (max 6 cycles) overall was 46%. The expected overall cumulative delivery percentage was 72%.
Multivariate examination did not array a powerful characteristic in complete potion of gonadotrophins used for ovarian stimulation between Chain A (in which the female companion was affected) and a force group. CONCLUSIONS: This scan shows that ICSI and PGD for DM1 attempt acceptable reproductive outcome, both in cumulative terms and per treatment cycle.
There is no evidence of impaired gonadal overhaul in female DM1 patients. Indispensable words: ICSI PGD myotonic dystrophy DM1 delivery degree Submitted on Nov 12, 2007; resubmitted on Jan 14, 2008; public on January 30, 2008. CiteULike Connotea Del.icio.us What's this? Disclaimer: Please message that abstracts for content published before 1996 were created digital scanning and may and so not correct replicate the subject of the virgin print issues.
