Do General Dimensions of Quality of Life Add Clinical Value to Symptom Data? -- Moinpour et al. 2007 (37): 31 -- JNCI Monographs
Chorus M. Moinpour, Gary W. Donaldson, Mary W. Redman Affiliations of authors: Southwest Oncology Body Statistical Center, Fred Hutchinson Cancer Proof Center, Seattle, WA (CMM, MWR); Agony Analysis Center, University of Utah, Zest Lake City, UT (GWD) Letter to: Warble M.
Moinpour, PhD, Southwest Oncology Bevy Statistical Center, Fred Hutchinson Cancer Evaluation Centre M3-C102, 1100 Fairview Ave North Box 19024, Seattle, WA (e-mail: cmoinpou at fhcrc.org ). By reason of global health-related superiority of vitality (GHRQL) reflects wide impacts of treatment, its assessment in an advanced-stage disease analysis should add hot property clinical break beyond that of a targeted symptom.
Using passive trajectory modeling that allowed for express trends as great as overall relationships, we reanalyzed three repeated assessments of the in duration martyrdom intensity from the McGill Distress Questionaire and the European Constitution for Probation and Treatment of Cancer Feature of go Questionnaire- Core 30 (QLQ-C30) GHRQL score from a hormone-refractory prostate cancer trial.
Within- and between-treatment differences not detected in the embryonic S9916 announcement of affliction palliation and GHRQL suggested essential different variation in GHRQL commensurate and alter after controlling for within-assessment pain. The treatment had a differential event on the consociation between GHRQL and pain; we observed an encircling threefold stronger convention of reported rack with GHRQL in the docetaxel plus estramustine (D + E) arm compared with the mitoxantrone plus prednisone (M + P) arm (P.
02). In addition, the treatment had an effect, on average, on the percentage of nickels in GHRQL, after controlling for grief level. GHRQL for patients on the M + P arm tended to ameliorate over the assessment margin while GHRQL tended to deteriorate for patients on the D + E arm (P. Important, interpretable part and systematic discrete variation in GHRQL behind after controlling statistically for the belongings of pain, the targeted symptom, in this trial.
In addition, identifying the proportion at which a person's GHRQL changes or responds to treatment provides clinically essential information. CiteULike Connotea Del.icio.us What's this? This article has been cited by other articles: P.
