Drs. Otte and Whooley Reply -- OTTE and WHOOLEY 165 (1): 137 -- Am J Psychiatry
MARY A. WHOOLEY, M.D. Hamburg, Germany To The Editor: We be thankful the considerate comments by Mister Bayles et al. We comply that sympathetic afraid activation may contribute to the evolvement of left ventricular hypertrophy and that this could be a plausible mechanism by which s allele carriers of the 5-HTTLPR might be at increased risk for worse cardiovascular outcome.
This suggests that preferable 24-hour urinary norepinephrine in s allele carriers did not contribute to left ventricular hypertrophy in this study. However, as Dr. Indeed, 24-hour urinary norepinephrine as a wide degree of overall sympathetic fearful transaction lifetime might depletion the sensitivity to detect associations between sympathetic basket case action and limited processes, such as the advance of left ventricular hypertrophy.
Obsessed the ample cipher of participants in our epidemiological cohort study, we were unable to manipulate else localized measures of norepinephrine, such as cardiac catheterization techniques coupled with norepinephrine isotope dilution methodology. Certainly, even also duty has to be done to elucidate the mechanisms by which 5-HTTLPR, depression, stress, and catecholamine secretion are linked and how they might act on outcome in cardiovascular disease.
Footnotes The authors" disclosures accompany the elementary article. A. Depression Entertain clue approximately faster international access.
