What next for preimplantation genetic screening? -- Harper et al., 10.1093 humrep dem424 -- Human Reproduction
The Author 2007. Published by Oxford University Press on behalf of the European State of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions oxfordjournals.org Contemporary Argument What adjoining for preimplantation genetic screening?
Joyce Harper 1, 13, Karen Sermon 2, Joep Geraedts 3, Katerina Vesela 4, Gary Harton 5, Alan Thornhill 6, Tugce Pehlivan 7, Francesco Fiorentino 8, Sioban SenGupta 1, Christine de Die-Smulders 9, Cristina Magli 10, Celine Moutou 11 and Leeanda Wilton 12 1 UCL Middle for PGD, School for Women's Health, University Faculty London, 86-96 Chenies Mews, WC1E6HX London, UK 2 Branch of Embryology and Genetics, Vrije Universiteit Brussel, Laarbeeklaan, 101, 1090 Brussels, Belgium 3 AZ Maastricht, Klinische Genetica, PO Box 5800, 6202 AZ Maastricht, The Netherlands 4 Sanatorium Repromeda, Vinini 235, 615 00 Brno, Czech State 5 Genetics and IVF Institute, 3015 Williams Drive, Fairfax, VA 22031, United states 6 The London Bridge Fertility, Gynecology and Genetics Centre, 1 St Thomas Street, London Bridge, London SE1 9RY, UK 7 Instituto Valenciano de Infertilidad, Plaza de la Policía Local, 3, 46015 Valencia, Spain 8 GENOMA, Molecular Genetics Laboratory, Via Po 102, 00198 Rome, Italy 9 PGD Working Band Maastricht, Department of Clinical Genetics, University Infirmary Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands 10 SISMER, Via Mazzini 12, 40138 Bologna, Italy 11 Work de la Biologie de la Reproduction, SIHCUS-CMCO, 19, Rue Louis Pasteur, BP120, 67303 Schiltigheim, France 12 Melbourne IVF, 320 Vic Parade, East Melbourne, 3002 VIC, Australia 13 Letter address.
Bountiful non-randomized PGS studies get been published and announcement an exaggeration in implantation rate, and or a shorten in miscarriage rate. Recently, two randomized controlled trials accept been conducted on patients with AMA as the solitary indication. Neither peruse showed a aid in performing PGS using vital birth percentage as the degree of success.
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