Heterozygosity for the Classical Galactosemia Mutation Does Not Affect Ovarian Reserve and Menopausal Age -- Knauff et al. 14 (8): 780 -- Reproductive Sciences
Reproductive Sciences, Vol. 14, No. H. Knauff, MD Branch of Reproduction and Gynecology, University Medical Center, Utrecht,The Netherlands, knauff at gmail.com Renate Richardus, MD Department of Pediatrics, Academic Medical Center, University of Amsterdam, The Netherlands Marinus J. Eijkemans, PhD Department of Usual Health, Erasmus Medical Center, Rotterdam, The Netherlands Regulate J. Broekmans, MD, PhD Department of Reproduction and Gynecology, University Medical Center, Utrecht,The Netherlands Sincere J.
Jong, PhD Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Bart C. J. M. Fauser, MD, PhD Department of Reproduction and Gynecology, University Medical Center, Utrecht,The Netherlands Annet M. Earlier probation has suggested an convention between heterozygosity for GALT mutations and early menopause. This recite evaluates the causatum of carriership for classical galactosemia on ovarian reserve and menopausal age.
Proven female carriers of classical galactosemia were recruited via the Dutch Galactosemia Society. All 58 participants underwent a structured interview regarding fertility, smoking status, and menopause. The niggardly hour at menopause in GALT carriers was 49.7 years, which is not differential from the close day at menopause in the usual population in the Netherlands. The authors conclude that there is no evidence that GALT mutation carriership affects ovarian reserve or menopausal age.
