Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7 -- Sugiyama et al. 20 (1): 1 -- International Immunology
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For permissions, please e-mail: journals.permissions oxfordjournals.org Immunoadjuvant object of polyadenylic:polyuridylic acids buttoned up TLR3 and TLR7 Takahiro Sugiyama 1, 2, Katsuaki Hoshino 1, Masuyoshi Saito 1, Takahiro Yano 1, Izumi Sasaki 1, Chihiro Yamazaki 1, Shizuo Akira 2 and Tsuneyasu Kaisho 1 1 Laboratory for Host Defense, RIKEN Probation Centre for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan 2 Branch of Host Defense, Proof Faculty for Microbial Diseases and Akira Innate Immunity Project, Exploratory Trial for Modern Technology, Japan Science and Technology Corporation, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan Send to : T.
Another type of dsRNA, polyadenylic:polyuridylic acids poly(A:U), can again reality as an unsusceptible adjuvant, nevertheless it remains unclear how it exhibits its adjuvant effects. Here, we own characterized the adjuvant factor of poly(A:U). IL-12p40 was further produced by poly(A:U)-stimulated pDC in a TLR7-dependent manner.
This IL-12p40 induction resulted from two cDC subsets, CD24 gigantic cDC and CD11b high-reaching cDC in a TLR3- and TLR7-dependent manner, respectively. Consistent with the in vitro findings, TLR3 and TLR7 were required for the clonal T-cell expansion.
Notably, TLR3, rather than TLR7, was critical for generating IFN- -producing CD8 + T cells. Keywords: dendritic cell, double-stranded RNA, unaffected adjuvant, Toll-like receptor Transmitting editor : K. Inaba Received 13 The middle of summer 2007, common 9 Oct 2007. Disclaimer: Please comment that abstracts for content published before 1996 were created concluded digital scanning and may so not equitable replicate the contents of the archetypal print issues.
