Hormone therapy and cognitive function -- Maki and Sundermann 15 (6): 667 -- Human Reproduction Update
Social Bookmarking What's this? The Author 2009. Published by Oxford University Press on behalf of the European Sovereign state of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions oxfordjournals.org Hormone therapy and cognitive service Pauline M. Maki 1 and Erin Sundermann Neuropsychiatric Institute, MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612, United states 1 Send address.
E-mail: pmaki at psych.uic.edu BACKGROUND: Clinical trials revenue discrepant hookup approximately the energy of hormone therapy on verbal remembrance and executive function.
This topic is clinically essential considering declines in verbal mind's eye are the earliest predictor of Alzheimer's disease and declines in executive advantage are central to some theories of normal, age-related changes in cognition. METHODS: We conducted a systematic inspection of randomized clinical trials of hormone therapy (i.e. 65 years; n 7) women and studies involving oestrogen alone versus estrogen plus progestogen.
Absent of 32 placebo-controlled trials, 17 were included (13 had no verbal recognition measures and 2 involved cholinergic manipulations). We as well feed a narrative check-up of 25 studies of executive avail (two trials), because there are inadequate clinical research information for systematic review.
RESULTS: There is some evidence for a favoring causatum of estrogen alone on verbal fame in younger naturally post-menopausal women and exceeding consistent evidence from small-n studies of surgically post-menopausal women. There is stronger evidence of a detrimental denouement of conjugated equine estrogen plus medroxyprogesterone acetate on verbal camera-eye in younger and older post-menopausal women.
Observational studies and pharmacological models of menopause dispense initial evidence of improvements in executive overhaul with hormone therapy. CONCLUSIONS: Forthcoming studies should carry measures of executive assistance and should superscription urgent clinical questions; including what formulation of combination hormone therapy is cognitively impartial beneficial, even effectual in treating fevered flashes in the early post-menopause.
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