Ovarian function after removal of an entire ovary for cryopreservation of pieces of cortex prior to gonadotoxic treatment: a follow-up study -- Rosendahl et al., 10.1093 humrep den248 -- Human Reproduction

The Author 2008. Published by Oxford University Press on behalf of the European Territory of Human Reproduction and Embryology. All rights reserved.

For Permissions, please email: journals.permissions oxfordjournals.org Ovarian assistance after emigration of an filled ovary for cryopreservation of pieces of cortex prior to gonadotoxic treatment: a follow-up glance at Mikkel Rosendahl 1, 2, 5, Claus Yding Andersen 1, Erik Ernst 3, Lars G.

Westergaard 4, Per Emil Rasmussen 4, Anne Loft 2 and Anders Nyboe Andersen 2 1 Laboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Denmark 2 The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Denmark 3 Reproductive Laboratory, Skejby University Hospital, Aarhus, Denmark 4 The Fertility Clinic, Odense University Hospital, Denmark 5 Mail address: E-mail: mikkel.rosendahl at rh.regionh.dk BACKGROUND: Ovarian servicing was studied in Danish patients who had ovarian tissue cryopreserved, and the patients' experiences with the procedure were investigated.

METHODS: There were 92 women who had an full ovary removed for cryopreservation 18-75 months earlier. Patients completed a questionnaire, and transvaginal ultrasonic antral follicle count and serum dialogue for follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH) were performed in 73 women.

RESULTS: In total, 11% of the BMT patients had usual ovarian function. Hodgkin's patients who particular received ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) ( n 12) and 60% of the breast cancer patients showed babyish evidence of ovarian damage. Accepted menstruation was shown to be a deluxe indicator of ovarian function.

The cryopreservation procedure scarcely complicated cancer treatment (5%) and 84% felt comforted as they had potentially secured their fertility. CONCLUSIONS: Cryopreservation of ovarian tissue should be considered in fresh female patients with Hodgkin's lymphoma receiving also aggressive treatment than ABVD and in patients scheduled for BMT. The urging for breast cancer patient should be individualized. The cryopreservation measure did not delay cancer treatment.

Principal words: fertility preservation cryopreservation ovarian reserve cancer AMH Submitted on Apr 10, 2008; resubmitted on May 26, 2008; universal on Jun 3, 2008. CiteULike Connotea Del.icio.us What's this? Disclaimer: Please sign that abstracts for content published before 1996 were created complete digital scanning and may accordingly not right replicate the words of the recent print issues.