Menopause - Abstract: Volume 14(6) November December 2007 p 978-984 Low-dose continuous combinations of hormone therapy and biochemical surrogate markers for vascular tone and inflammation: transdermal
The consequent markers or their steady metabolites in serum or urine were assessed: P-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, monocyte chemoattractant protein-1, matrix metalloproteinase-9, homocysteine, cyclic guanosine monophosphate, serotonin, prostacyclin, thromboxane, and urodilatin.
Matrix metalloproteinase-9 was increased particular by spoken HT. The urinary concentrations of cyclic guanosine monophosphate, the ratio of prostacyclin to thromboxane metabolite, and the serotonin metabolite were significantly increased for both HT manipulate modes, although the said treatment showed a significantly higher quality boost than the transdermal one with fear to baseline.
Urodilatin excretion was increased apart by the verbal regimen. Conclusions: Low-dose transdermal and vocal HTs using E2 and NETA derive favourable thing on cardiovascular biochemical markers. If these differences may be attributed to the at odds government routes or to contradistinct pharmacokinetic properties remains an free question. Overall low-dose transdermal HT seems to provoke the alike relieve on the cardiovascular course as uttered HT, as suggested by the results on vascular markers. All rights reserved.
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